Peroxiredoxin 6 mediates Gαi protein-coupled receptor inactivation by cJun kinase

Opioid receptors are important modulators of nociceptive pain. Here the authors show that opioid receptor activation recruits peroxiredoxin 6 (PRDX6) to the receptor-Gαi complex by c-Jun N-terminal kinase, resulting in Gαi depalmitoylation and enhanced receptor-Gαi association.

Dades bibliogràfiques

Autors principals:	Selena S. Schattauer, Benjamin B. Land, Kathryn L. Reichard, Antony D. Abraham, Lauren M. Burgeno, Jamie R. Kuhar, Paul E. M. Phillips, Shao En Ong, Charles Chavkin
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2017-09-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-017-00791-2
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