Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians

In contrast to transcriptional regulation, the function of alternative splicing (AS) in stem cells is poorly understood. In mammals, MBNL proteins negatively regulate an exon program specific of embryonic stem cells; however, little is known about the in vivo significance of this regulation. We stud...

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Autors principals:	Jordi Solana, Manuel Irimia, Salah Ayoub, Marta Rodriguez Orejuela, Vera Zywitza, Marvin Jens, Javier Tapial, Debashish Ray, Quaid Morris, Timothy R Hughes, Benjamin J Blencowe, Nikolaus Rajewsky
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2016-08-01
Col·lecció:	eLife
Matèries:	stem cells Schmidtea mediterranea alternative splicing post-transcriptional gene regulation regeneration planaria
Accés en línia:	https://elifesciences.org/articles/16797
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