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Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians

In contrast to transcriptional regulation, the function of alternative splicing (AS) in stem cells is poorly understood. In mammals, MBNL proteins negatively regulate an exon program specific of embryonic stem cells; however, little is known about the in vivo significance of this regulation. We stud...

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Principais autores: Jordi Solana, Manuel Irimia, Salah Ayoub, Marta Rodriguez Orejuela, Vera Zywitza, Marvin Jens, Javier Tapial, Debashish Ray, Quaid Morris, Timothy R Hughes, Benjamin J Blencowe, Nikolaus Rajewsky
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2016-08-01
Serier:eLife
Fag:
stem cells
Schmidtea mediterranea
alternative splicing
post-transcriptional gene regulation
regeneration
planaria
Online adgang:https://elifesciences.org/articles/16797
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