Spatiotemporally specific roles of TLR4, TNF, and IL-17A in murine endotoxin-induced inflammation inferred from analysis of dynamic networks

Abstract Background Bacterial lipopolysaccharide (LPS) induces a multi-organ, Toll-like receptor 4 (TLR4)-dependent acute inflammatory response. Methods Using network analysis, we defined the spatiotemporal dynamics of 20, LPS-induced, protein-level inflammatory mediators over 0–48 h in the heart, g...

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Principais autores:	Ruben Zamora, Sangeeta Chavan, Theodoros Zanos, Richard L. Simmons, Timothy R. Billiar, Yoram Vodovotz
格式:	Artigo
語言:	Inglês
出版:	BMC 2021-06-01
叢編:	Molecular Medicine
主題:	Endotoxemia Endotoxin Lipopolysaccharide TLR4 Cytokines Chemokines
在線閱讀:	https://doi.org/10.1186/s10020-021-00333-z
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