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Small-molecule screen reveals pathways that regulate C4 secretion in stem cell-derived astrocytes

Summary: In the brain, the complement system plays a crucial role in the immune response and in synaptic elimination during normal development and disease. Here, we sought to identify pathways that modulate the production of complement component 4 (C4), recently associated with an increased risk of...

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Hoofdauteurs: Francesca Rapino, Ted Natoli, Francesco Limone, Erin O’Connor, Jack Blank, Matthew Tegtmeyer, William Chen, Erika Norabuena, Juhi Narula, Dane Hazelbaker, Gabriella Angelini, Lindy Barrett, Alison O’Neil, Ursula K. Beattie, Jessica M. Thanos, Heather de Rivera, Steven D. Sheridan, Roy H. Perlis, Steven A. McCarroll, Beth Stevens, Aravind Subramanian, Ralda Nehme, Lee L. Rubin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Elsevier 2023-01-01
Reeks:Stem Cell Reports
Onderwerpen:
human induced pluripotent stem cells
iPSCs
human embryonic stem cells
ESCs
astrocytes
stem cell-derived astrocytes
Online toegang:http://www.sciencedirect.com/science/article/pii/S2213671122005513
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