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An Integrated Approach toward NanoBRET Tracers for Analysis of GPCR Ligand Engagement

Gaining insight into the pharmacology of ligand engagement with G-protein coupled receptors (GPCRs) under biologically relevant conditions is vital to both drug discovery and basic research. NanoLuc-based bioluminescence resonance energy transfer (NanoBRET) monitoring competitive binding between flu...

Täydet tiedot

Tallennettuna:
Päätekijät: Michael P. Killoran, Sergiy Levin, Michelle E. Boursier, Kristopher Zimmerman, Robin Hurst, Mary P. Hall, Thomas Machleidt, Thomas A. Kirkland, Rachel Friedman Ohana
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: MDPI AG 2021-05-01
Sarja:Molecules
Aiheet:
GPCRS
ligand-engagement
NanoBRET
HiBiT
in silico screen
Linkit:https://www.mdpi.com/1420-3049/26/10/2857
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