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Identification of a lactylation-related gene signature in microsatellite stable gastric cancer based on bulk and single-cell RNA-seq

BackgroundMicrosatellite stable (MSS) gastric cancer (GC) responds poorly to immunotherapy and exhibits heterogeneous outcomes. Histone lactylation plays a critical role in cancer progression. However, the prognostic and therapeutic potential of a lactylation-related gene signature (LRGS) in MSS GC...

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Principais autores: Zhong-Tai Lin, Yuan-Chun Chen, Li-Sheng You, Yuan-Zhao Wang, Xiang-Yu Wang, Liang-Jie Chi
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-05-01
coleção:Frontiers in Immunology
Assuntos:
gastric cancer
immunotherapy
lactylation-related genes
microsatellite stable
single-cell analysis
tumor microenvironment
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1838771/full
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