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Ascophyllan Supplementation Is Safe and Associated with Exploratory Modulation of Innate Immune Phenotypes, Biochemical Parameters, and the Gut Microbiome in a Randomized Pilot Trial

Background: Ascophyllan, a sulfated polysaccharide extracted from brown seaweed, has shown immunomodulatory and antioxidant effects in preclinical studies, yet human clinical evidence remains scarce. This randomized, double-blind, placebo-controlled pilot trial evaluated the safety and exploratory b...

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Principais autores: Shohei Mizuno, Jorge Luis Espinoza, Lam Quang Vu, Hirona Banno, Yusuke Iida, Saki Shinohara, Do Tung Dac, Yuya Nakagami, Kaori Uchino, Tomohiro Horio, Ichiro Hanamura, Nobuhiro Asai, Megumi Enomoto, Hiroya Tani, Takayuki Nakayama, Susumu Suzuki, Akiyoshi Takami
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-06-01
Serier:Marine Drugs
Fag:
ascophyllan
natural killer cells
innate immunity
gut microbiome
functional dietary polysaccharide
Online adgang:https://www.mdpi.com/1660-3397/24/6/213
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