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Long-term HBsAg clearance, relapse, and safety following tenofovir or entecavir discontinuation in non-cirrhotic, HBeAg-negative chronic hepatitis

Abstract Stopping nucleos(t)ide analogues (NAs) can foster hepatitis B surface antigen (HBsAg) clearance, yet comparative data for tenofovir disoproxil fumarate (TDF) and entecavir (ETV) are scarce. We compared HBsAg loss, virological relapse (VR), clinical relapse (CR), and safety after stopping TD...

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Principais autores: Onuma Sattayalertyanyong, Wimolrak Bandidniyamanon, Julajak Limsrivilai, Watcharasak Chotiyaputta, Supot Nimanong, Tawesak Tanwandee
Formato: Artigo
Idioma:Inglês
Publicado: Nature Portfolio 2026-02-01
Series:Scientific Reports
Assuntos:
Hepatitis B
Chronic
Hepatitis B surface antigens
Entecavir
Tenofovir
Withholding treatment
Acceso en liña:https://doi.org/10.1038/s41598-026-40972-y
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