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UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function. Using a...

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I tiakina i:
Ngā kaituhi matua: Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Wiley 2026-08-01
Rangatū:Advanced Science
Ngā marau:
biomolecular condensates
dengue
deubiquitylases
sfRNA
Zika
Urunga tuihono:https://doi.org/10.1002/advs.202521781
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