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UCHL3 Regulates Subgenomic Flaviviral RNA Condensates to Promote Virus Propagation

ABSTRACT Flavivirus subgenomic RNAs (sfRNAs) antagonise antiviral defences, yet how sfRNAs are organized and maintained in cells remains poorly understood. Here we identify ubiquitin C‐terminal hydrolase L3 (UCHL3) as a post‐translational regulator of flavivirus sfRNA stability and function. Using a...

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Principais autores: Oscar Trejo‐Cerro, Anna Beekmayer‐Dhillon, Qi Wen Teo, Lewis Siu, Ming Yuan Li, Kate J. Heesom, Adán Pinto‐Fernández, Sumana Sanyal
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-08-01
Serier:Advanced Science
Fag:
biomolecular condensates
dengue
deubiquitylases
sfRNA
Zika
Online adgang:https://doi.org/10.1002/advs.202521781
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