Combining spironolactone to antiretroviral therapy accelerates HIV decay in humanized mice

Spironolactone (SP), a clinically used aldosterone antagonist, has been explored as an anti-HIV agent in models of HIV-1 latency for inducing transcriptional silencing of the viral reservoir. SP promotes the degradation of xeroderma pigmentosum group B (XPB) protein, a crucial component of transcrip...

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Egile Nagusiak:	Lijun Ling, Luisa P. Mori, Andrew Soper, Wenbo Yao, Andrew T. McAuley, Ana R. Leda, Rae Ann Spagnuolo, Nurjahan Begum, Martina Kovarova, Angela Wahl, Michael D. Cameron, Susana T. Valente, J. Victor Garcia
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Taylor & Francis Group 2025-12-01
Saila:	Emerging Microbes and Infections
Gaiak:	Spironolactone HIV-1 transcription latency-promoting agents humanized mouse model Chronic inflammation
Sarrera elektronikoa:	https://www.tandfonline.com/doi/10.1080/22221751.2025.2589549
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