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Combining spironolactone to antiretroviral therapy accelerates HIV decay in humanized mice

Spironolactone (SP), a clinically used aldosterone antagonist, has been explored as an anti-HIV agent in models of HIV-1 latency for inducing transcriptional silencing of the viral reservoir. SP promotes the degradation of xeroderma pigmentosum group B (XPB) protein, a crucial component of transcrip...

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Principais autores: Lijun Ling, Luisa P. Mori, Andrew Soper, Wenbo Yao, Andrew T. McAuley, Ana R. Leda, Rae Ann Spagnuolo, Nurjahan Begum, Martina Kovarova, Angela Wahl, Michael D. Cameron, Susana T. Valente, J. Victor Garcia
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2025-12-01
Serier:Emerging Microbes and Infections
Fag:
Spironolactone
HIV-1 transcription
latency-promoting agents
humanized mouse model
Chronic inflammation
Online adgang:https://www.tandfonline.com/doi/10.1080/22221751.2025.2589549
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