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Enzymatic modification of low density lipoprotein by purified lipoxygenase plus phospholipase A2 mimics cell-mediated oxidative modification

Low density lipoprotein (LDL) can be oxidatively modified by cultured endothelial cells or by cupric ions, resulting in increased macrophage uptake of the lipoprotein. This process could be relevant to the formation of macrophage-derived foam cells in the early atherosclerotic lesion. The mechanism...

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Detalles Bibliográficos
Principais autores: C P Sparrow, S Parthasarathy, D Steinberg
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 1988-06-01
Series:Journal of Lipid Research
Acceso en liña:http://www.sciencedirect.com/science/article/pii/S0022227520384935
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