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A multistate stem cell dynamics maintains homeostasis in mouse spermatogenesis

Summary: In mouse testis, a heterogeneous population of undifferentiated spermatogonia (Aundiff) harbors spermatogenic stem cell (SSC) potential. Although GFRα1+ Aundiff maintains the self-renewing pool in homeostasis, the functional basis of heterogeneity and the implications for their dynamics rem...

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Furkejuvvon:
Váldodahkkit: Toshinori Nakagawa, David J. Jörg, Hitomi Watanabe, Seiya Mizuno, Seungmin Han, Tatsuro Ikeda, Yoshiki Omatsu, Keiko Nishimura, Miyako Fujita, Satoru Takahashi, Gen Kondoh, Benjamin D. Simons, Shosei Yoshida, Takashi Nagasawa
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Elsevier 2021-10-01
Ráidu:Cell Reports
Fáttát:
spermatogenic stem cells
stem cell heterogeneity
lineage tracing
Plvap
Sox3
tissue homeostasis
Liŋkkat:http://www.sciencedirect.com/science/article/pii/S2211124721013425
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