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Properdin Modulates Complement Component Production in Stressed Human Primary Retinal Pigment Epithelium Cells

The retinal pigment epithelium (RPE) maintains visual function and preserves structural integrity of the retina. Chronic dysfunction of the RPE is associated with retinal degeneration, including age-related macular degeneration (AMD). The AMD pathogenesis includes both increased oxidative stress and...

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Principais autores: Nicole Schäfer, Hannah N. Wolf, Anne Enzbrenner, Juliane Schikora, Maria Reichenthaler, Volker Enzmann, Diana Pauly
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-08-01
Serier:Antioxidants
Fag:
retinal pigment epithelium
complement system
properdin
AMD-risk genotype
intracellular
cell-associated
Online adgang:https://www.mdpi.com/2076-3921/9/9/793
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