Integrating Human Intestinal Organoids into FDA's New Approach Methodologies for Drug Discovery

ABSTRACT Reliance on cell lines and animal models for toxicity testing has long been the cornerstone of preclinical drug discovery for intestinal diseases, but the physiology, genetics, and disease etiology of animals differ significantly from those of humans. Species‐specific differences contribute...

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Principais autores:	Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Wiley 2026-04-01
Colecção:	Advanced Science
Assuntos:	drug discovery FDA's new approach methodologies gastrointestinal toxicity human intestinal organoids inflammatory bowel disease
Acesso em linha:	https://doi.org/10.1002/advs.202522276
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