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Integrating Human Intestinal Organoids into FDA's New Approach Methodologies for Drug Discovery

ABSTRACT Reliance on cell lines and animal models for toxicity testing has long been the cornerstone of preclinical drug discovery for intestinal diseases, but the physiology, genetics, and disease etiology of animals differ significantly from those of humans. Species‐specific differences contribute...

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Principais autores: Debarun Patra, Ibrahim M. Sayed, Souhrid Mukherjee, Honit Piplani, Aida Habtezion, Michael J. Rosen, Jospeh C. Wu
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2026-04-01
Serier:Advanced Science
Fag:
drug discovery
FDA's new approach methodologies
gastrointestinal toxicity
human intestinal organoids
inflammatory bowel disease
Online adgang:https://doi.org/10.1002/advs.202522276
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