Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation

Loss-of-function mutations in cerebral cavernous malformation (CCM) genes and gain-of-function mutation in the MAP3K3 gene encoding MEKK3 cause CCM. Deficiency of CCM proteins leads to the activation of MEKK3-KLF2/4 signaling, but it is not clear how this occurs. Here, we demonstrate that deletion o...

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Principais autores:	Xi Yang, Shi-Ting Wu, Rui Gao, Rui Wang, Yixuan Wang, Zhenkun Dong, Lu Wang, Chunxiao Qi, Xiaohong Wang, M. Lienhard Schmitz, Renjing Liu, Zhiming Han, Xiangjian Zheng
格式:	Artigo
語言:	Inglês
出版:	American Society for Clinical investigation 2023-03-01
叢編:	JCI Insight
主題:	Angiogenesis Vascular biology
在線閱讀:	https://doi.org/10.1172/jci.insight.160372
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