Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation
Loss-of-function mutations in cerebral cavernous malformation (CCM) genes and gain-of-function mutation in the MAP3K3 gene encoding MEKK3 cause CCM. Deficiency of CCM proteins leads to the activation of MEKK3-KLF2/4 signaling, but it is not clear how this occurs. Here, we demonstrate that deletion o...
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| Autori principali: | , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical investigation
2023-03-01
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| Serie: | JCI Insight |
| Soggetti: | |
| Accesso online: | https://doi.org/10.1172/jci.insight.160372 |
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