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R-loop resolution promotes co-transcriptional chromatin silencing

Nascent non-coding RNA can mediate chromatin silencing, however mechanistically this process is poorly understood. Here the authors show that resolution of an R-loop during 3'-end processing of a plant antisense transcript recruits chromatin modifiers to promote chromatin silencing.

I tiakina i:
Ngā taipitopito rārangi puna kōrero
Ngā kaituhi matua: Congyao Xu, Zhe Wu, Hong-Chao Duan, Xiaofeng Fang, Guifang Jia, Caroline Dean
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Nature Portfolio 2021-03-01
Rangatū:Nature Communications
Urunga tuihono:https://doi.org/10.1038/s41467-021-22083-6
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