PlexinD1 is a driver and a therapeutic target in advanced prostate cancer

Abstract Aggressive prostate cancer (PCa) variants associated with androgen receptor signaling inhibitor (ARSI) resistance and metastasis remain poorly understood. Here, we identify the axon guidance semaphorin receptor PlexinD1 as a crucial driver of cancer aggressiveness in metastatic castration-r...

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Podrobná bibliografie

Hlavní autoři:	Jing Wei, Jing Wang, Wen Guan, Jingjing Li, Tianjie Pu, Eva Corey, Tzu-Ping Lin, Allen C Gao, Boyang Jason Wu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer Nature 2025-01-01
Edice:	EMBO Molecular Medicine
Témata:	Castration-resistant Prostate Cancer Cellular Plasticity Neuroendocrine Differentiation Androgen Receptor Signaling inhibitors PlexinD1
On-line přístup:	https://doi.org/10.1038/s44321-024-00186-z
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