The origin of Rosenthal fibers and their contributions to astrocyte pathology in Alexander disease
Abstract Rosenthal fibers (RFs) are cytoplasmic, proteinaceous aggregates. They are the pathognomonic feature of the astrocyte pathology in Alexander Disease (AxD), a neurodegenerative disorder caused by heterozygous mutations in the GFAP gene, encoding glial fibrillary acidic protein (GFAP). Althou...
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| Principais autores: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BMC
2017-03-01
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| Serier: | Acta Neuropathologica Communications |
| Fag: | |
| Online adgang: | http://link.springer.com/article/10.1186/s40478-017-0425-9 |
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