Exploring the active ingredients and potential mechanisms of Pingchan granules in Parkinson’s disease treatment through network pharmacology and transcriptomics

Abstract Parkinson’s disease (PD), the second most prevalent neurodegenerative disorder, poses significant challenges to single-target therapeutic strategies due to its complex etiology. This has driven interest in multi-target approaches, particularly those leveraging natural compounds. Pingchan gr...

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Autors principals:	Qiu-Han Xu, Yi-Ling Wang, Cheng Wang, Si-Si Jiang, Bao-Rong Zhang, Jun Tian
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2025-03-01
Col·lecció:	Scientific Reports
Matèries:	Parkinson’s disease Pingchan granules Network Pharmacology Single-cell nuclear sequencing Molecular dynamics simulation Mendelian randomization
Accés en línia:	https://doi.org/10.1038/s41598-025-91344-x
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