Design and Pictet–Spengler enabled synthesis of carboxamide-substituted imidazo[1,2-a]quinoxalines as dual EGFR and tubulin targeting anticancer agents

In this study, we report the Pictet–Spengler enabled synthesis of a series of eighteen carboxamide-substituted imidazo[1,2-a]quinoxaline derivatives (JRC-1-JRC-18) targeting epidermal growth factor receptor (EGFR) and tubulin. Compounds JRC-2 and JRC-6 exhibited potent antiproliferative effects agai...

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Huvudupphov:	Joydeep Chatterjee, Gaurav Joshi, Vibhu Jha, Shivkanya M. Bhujbal, Shivani Rathour, Sanjana Majumdar, Muhammad Wahajuddin, Prasad V. Bharatam, Raj Kumar
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Taylor & Francis Group 2026-12-01
Serie:	Journal of Enzyme Inhibition and Medicinal Chemistry
Ämnen:	EGFR kinase inhibition tubulin polymerisation dual-target anticancer agents ROS-mediated apoptosis molecular docking and dynamics
Länkar:	https://www.tandfonline.com/doi/10.1080/14756366.2026.2673744
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