Structural and functional insights into the iminium ion intermediate in AsKslB-mediated Pictet-Spengler reaction

Pictet-Spengler (PS) reactions are pivotal in the biosynthesis of bioactive alkaloids and pharmaceuticals, yet key structural details underlying their enzymatic catalysis remain insufficiently understood. We identified AsKslB from Actinosynnema sp. ALI-1.44 as a Pictet-Spenglerase with broad substra...

Полное описание

Библиографические подробности

Главные авторы:	Yan-Bin Teng, Zhi Qiao, Chunya Xie, Xiaona Yang, Xinyu Liu, Zhengrong Zou, Yunchang Xie, Xuan Zhang, Qi Chen
Формат:	Artigo
Язык:	Inglês
Опубликовано:	KeAi Communications Co., Ltd. 2026-03-01
Серии:	Synthetic and Systems Biotechnology
Предметы:	β-carboline alkaloids Enzyme reaction Crystal structure Pictet-Spenglerase Iminium ion intermediate AsKslB
Online-ссылка:	http://www.sciencedirect.com/science/article/pii/S2405805X25001589
Метки:	Добавить метку Нет меток, Требуется 1-ая метка записи!