Structural and functional insights into the iminium ion intermediate in AsKslB-mediated Pictet-Spengler reaction

Pictet-Spengler (PS) reactions are pivotal in the biosynthesis of bioactive alkaloids and pharmaceuticals, yet key structural details underlying their enzymatic catalysis remain insufficiently understood. We identified AsKslB from Actinosynnema sp. ALI-1.44 as a Pictet-Spenglerase with broad substra...

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Autori principali:	Yan-Bin Teng, Zhi Qiao, Chunya Xie, Xiaona Yang, Xinyu Liu, Zhengrong Zou, Yunchang Xie, Xuan Zhang, Qi Chen
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	KeAi Communications Co., Ltd. 2026-03-01
Serie:	Synthetic and Systems Biotechnology
Soggetti:	β-carboline alkaloids Enzyme reaction Crystal structure Pictet-Spenglerase Iminium ion intermediate AsKslB
Accesso online:	http://www.sciencedirect.com/science/article/pii/S2405805X25001589
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