Suppressing Wnt signaling of the blood‒tumor barrier to intensify drug delivery and inhibit lipogenesis of brain metastases

Lipogenesis is often highly upregulated in breast cancer brain metastases to adapt to intracranial low lipid microenvironments. Lipase inhibitors hold therapeutic potential but their intra-tumoral distribution is often blocked by the blood‒tumor barrier (BTB). BTB activates its Wnt signaling to main...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Yang Tong, Pei An, Puxian Tang, Rui Mu, Yuteng Zeng, Hang Sun, Mei Zhao, Ziyan Lv, Pan Wang, Wanjun Han, Chunshan Gui, Xuechu Zhen, Liang Han
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2024-06-01
Schriftenreihe:	Acta Pharmaceutica Sinica B
Schlagworte:	Lipogenesis Brain metastases Blood‒tumor barrier Wnt signaling Drug delivery Fatty acid synthase
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2211383524001059
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!