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Improving the performance of polymerase chain reaction for microsatellite instability testing in endometrial cancer

Abstract Between 20% and 30% of endometrial cancer (EC) cases show mismatch repair deficiency (dMMR), and its characterisation is recommended in these tumours for molecular classification, screening of Lynch syndrome, and as a predictive biomarker for immunotherapy. The aim of this study was to expl...

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Principais autores: Marta Mendiola, Victoria Heredia-Soto, Amparo Baillo, Ignacio Ruz-Caracuel, Rocio Mena, Alberto Berjón, Francisco Javier Escudero, Jorge Pedregosa, Alicia Hernandez, Jaime Feliu, David Hardisson, Andres Redondo
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2025-12-01
Serier:Scientific Reports
Fag:
Endometrial carcinoma
Mismatch repair deficiency
Microsatellite instability
Polymerase chain reaction
OncoMate
Long mononucleotide repeats
Online adgang:https://doi.org/10.1038/s41598-025-27895-w
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