Integrating functional data to prioritize causal variants in statistical fine-mapping studies.

Standard statistical approaches for prioritization of variants for functional testing in fine-mapping studies either use marginal association statistics or estimate posterior probabilities for variants to be causal under simplifying assumptions. Here, we present a probabilistic framework that integr...

Disgrifiad llawn

Manylion Llyfryddiaeth

Prif Awduron:	Gleb Kichaev, Wen-Yun Yang, Sara Lindstrom, Farhad Hormozdiari, Eleazar Eskin, Alkes L Price, Peter Kraft, Bogdan Pasaniuc
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Public Library of Science (PLoS) 2014-10-01
Cyfres:	PLoS Genetics
Mynediad Ar-lein:	http://europepmc.org/articles/PMC4214605?pdf=render
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!