MARS: leveraging allelic heterogeneity to increase power of association testing
Abstract In standard genome-wide association studies (GWAS), the standard association test is underpowered to detect associations between loci with multiple causal variants with small effect sizes. We propose a statistical method, Model-based Association test Reflecting causal Status (MARS), that fi...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2021-04-01
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| coleção: | Genome Biology |
| Assuntos: | |
| Acesso em linha: | https://doi.org/10.1186/s13059-021-02353-8 |
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