Increased cerebrospinal fluid and plasma apoE glycosylation is associated with reduced levels of Alzheimer’s disease biomarkers

Abstract The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD). ApoE is glycosylated with an O-linked Core-1 sialylated glycan at several sites; however, the impact and function of this glycosylation on AD biomarkers remain unclear. We exa...

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Hauptverfasser:	Dobrin Nedelkov, Zoe E. Tsokolas, Matheus Scarpatto Rodrigues, Isabel Sible, S. Duke Han, Bilal E. Kerman, Michael Renteln, Wendy J. Mack, Tharick A. Pascoal, Hussein N. Yassine, the Alzheimer’s Disease Neuroimaging Initiative
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2025-07-01
Schriftenreihe:	Alzheimer’s Research & Therapy
Schlagworte:	Apolipoprotein E Isoform Glycan Biomarkers Alzheimer’s disease
Online-Zugang:	https://doi.org/10.1186/s13195-025-01795-7
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