Increased cerebrospinal fluid and plasma apoE glycosylation is associated with reduced levels of Alzheimer’s disease biomarkers

Abstract The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease (AD). ApoE is glycosylated with an O-linked Core-1 sialylated glycan at several sites; however, the impact and function of this glycosylation on AD biomarkers remain unclear. We exa...

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Bibliografiske detaljer

Principais autores:	Dobrin Nedelkov, Zoe E. Tsokolas, Matheus Scarpatto Rodrigues, Isabel Sible, S. Duke Han, Bilal E. Kerman, Michael Renteln, Wendy J. Mack, Tharick A. Pascoal, Hussein N. Yassine, the Alzheimer’s Disease Neuroimaging Initiative
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMC 2025-07-01
Serier:	Alzheimer’s Research & Therapy
Fag:	Apolipoprotein E Isoform Glycan Biomarkers Alzheimer’s disease
Online adgang:	https://doi.org/10.1186/s13195-025-01795-7
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