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Alpha-1 antitrypsin inhibits Clostridium botulinum C2 toxin, Corynebacterium diphtheriae diphtheria toxin and B. anthracis fusion toxin

Abstract The bacterium Clostridium botulinum, well-known for producing botulinum neurotoxins, which cause the severe paralytic illness known as botulism, produces C2 toxin, a binary AB-toxin with ADP-ribosyltranferase activity. C2 toxin possesses two separate protein components, an enzymatically act...

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Principais autores: Stefanie Lietz, Lena-Marie Sokolowski, Holger Barth, Katharina Ernst
Format: Artigo
Sprog:Inglês
Udgivet: Nature Portfolio 2024-09-01
Serier:Scientific Reports
Fag:
α1-Antitrypsin
Toxin inhibitor
Clostridium botulinum C2 toxin
Diphtheria toxin
Anthrax toxin
Drug repurposing
Online adgang:https://doi.org/10.1038/s41598-024-71706-7
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