INSIGHTS INTO THE PATHOLOGY OF THE α2-Na+/K+-ATPase IN NEUROLOGICAL DISORDERS; LESSONS FROM ANIMAL MODELS

A functional Na+/K+-ATPase consists of a catalytic α subunit and a regulatory β subunit. Four α isoforms of the Na+/K+-ATPase are found in mammals, each with a unique expression pattern and catalytic activity. The α2 isoform, encoded by the ATP1A2 gene, is primarily found in the central nervous syst...

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Autors principals:	Toke Jost Isaksen, Karin eLykke-Hartmann
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2016-05-01
Col·lecció:	Frontiers in Physiology
Matèries:	Astrocytes Glutamate mouse models Familial hemiplegic migraine type 2 (FHM2) α2 sodium ion pump
Accés en línia:	http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00161/full
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