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INSIGHTS INTO THE PATHOLOGY OF THE α2-Na+/K+-ATPase IN NEUROLOGICAL DISORDERS; LESSONS FROM ANIMAL MODELS

A functional Na+/K+-ATPase consists of a catalytic α subunit and a regulatory β subunit. Four α isoforms of the Na+/K+-ATPase are found in mammals, each with a unique expression pattern and catalytic activity. The α2 isoform, encoded by the ATP1A2 gene, is primarily found in the central nervous syst...

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Principais autores: Toke Jost Isaksen, Karin eLykke-Hartmann
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2016-05-01
סדרה:Frontiers in Physiology
נושאים:
Astrocytes
Glutamate
mouse models
Familial hemiplegic migraine type 2 (FHM2)
α2 sodium ion pump
גישה מקוונת:http://journal.frontiersin.org/Journal/10.3389/fphys.2016.00161/full
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