Coexpression of GSK-3β Corrects Phenotypic Aberrations of Dorsal Root Ganglion Cells, Cultured from Adult Transgenic Mice Overexpressing Human Protein tau

Coexpression of constitutively active GSK-3β[S9A] rescued the axonal pathology induced by overexpression of human tau in transgenic mice (Spittaels et al., (2000) J. Biol. Chem. 275, 41340–41349). We isolated dorsal root ganglion (DRG) neuronal cultures from adult tau4R- and tau4R × GSK-3β-transgeni...

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Bibliografiske detaljer

Principais autores:	R. Nuydens, G. Van Den Kieboom, C. Nolten, C. Verhulst, P. Van Osta, K. Spittaels, C. Van den Haute, E. De Feyter, H. Geerts, F. Van Leuven
Format:	Artigo
Sprog:	Inglês
Udgivet:	Elsevier 2002-02-01
Serier:	Neurobiology of Disease
Fag:	tau GSK-3β microtubules dorsal root ganglion neuron transgenics axonal transport
Online adgang:	http://www.sciencedirect.com/science/article/pii/S0969996101904541
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