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Single-cell spatial proteomic imaging for human neuropathology

Abstract Neurodegenerative disorders are characterized by phenotypic changes and hallmark proteopathies. Quantifying these in archival human brain tissues remains indispensable for validating animal models and understanding disease mechanisms. We present a framework for nanometer-scale, spatial prot...

Deskribapen osoa

Gorde:
Egile Nagusiak: Kausalia Vijayaragavan, Bryan J. Cannon, Dmitry Tebaykin, Marc Bossé, Alex Baranski, J. P. Oliveria, Syed A. Bukhari, Dunja Mrdjen, M. Ryan Corces, Erin F. McCaffrey, Noah F. Greenwald, Yari Sigal, Diana Marquez, Zumana Khair, Trevor Bruce, Mako Goldston, Anusha Bharadwaj, Kathleen S. Montine, R. Michael Angelo, Thomas J. Montine, Sean C. Bendall
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BMC 2022-11-01
Saila:Acta Neuropathologica Communications
Sarrera elektronikoa:https://doi.org/10.1186/s40478-022-01465-x
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