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Modelling of clinical TQT studies outcomes from preclinical cardiovascular safety pharmacology studies using the one-step QTc model

IntroductionRetrospective translational analyses have shown a high rate of false negatives between clinical thorough QT studies (TQT) and preclinical cardiovascular safety pharmacology studies. The aim of this work was to model the results of clinical TQT studies from cardiovascular safety pharmacol...

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Principais autores: Pascal Champéroux, Raafat Fares, Derek Leishman
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-10-01
Serier:Frontiers in Pharmacology
Fag:
electrocardiogram
QT interval correction
safety pharmacology
hERG blockers
QT prolongation
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2025.1619547/full
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