Applications of Dynamic Clamp to Cardiac Arrhythmia Research: Role in Drug Target Discovery and Safety Pharmacology Testing

Dynamic clamp, a hybrid-computational-experimental technique that has been used to elucidate ionic mechanisms underlying cardiac electrophysiology, is emerging as a promising tool in the discovery of potential anti-arrhythmic targets and in pharmacological safety testing. Through the injection of co...

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Principais autores:	Francis A. Ortega, Eleonora Grandi, Trine Krogh-Madsen, David J. Christini
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2018-01-01
Colecção:	Frontiers in Physiology
Assuntos:	dynamic clamp cardiac electrophysiology cardiac modeling arrhythmia mechanisms antiarrhythmic drugs pharmacology & drug discovery
Acesso em linha:	http://journal.frontiersin.org/article/10.3389/fphys.2017.01099/full
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