SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression

Abstract Adipocyte dysfunction correlates with the development of diabetes. Here we show that mice with a adipocyte-specific deletion of the SUMO-specific protease SENP1 gene develop symptoms of type-1 diabetes mellitus (T1DM), including hyperglycaemia and glucose intolerance with mild insulin resis...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Lan Shao, Huanjiao Jenny Zhou, Haifeng Zhang, Lingfeng Qin, John Hwa, Zhong Yun, Weidong Ji, Wang Min
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Nature Portfolio 2015-11-01
Sarja:	Nature Communications
Linkit:	https://doi.org/10.1038/ncomms9917
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