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Lesional senescent CD4+ T cells mediate bystander cytolysis and contribute to the skin pathology of human cutaneous leishmaniasis

Cytotoxic activity is a hallmark of the immunopathogenesis in human cutaneous leishmaniasis (CL). In this study, we identified accumulation of CD4+ granzyme B producing T cells with increased cytotoxic capacity in CL lesions. These cells showed enhanced expression of activating NK receptors (NKG2D a...

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Autori principali: Luciana Polaco Covre, Carlos Henrique Fantecelle, Renan Garcia de Moura, Paola Oliveira Lopes, Isabela Valim Sarmento, Celio Geraldo Freire-de-Lima, Debora Decote-Ricardo, Herbert Leonel de Matos Guedes, Alessandra Marcia da Fonsceca-Martins, Lucas Pedreira de Carvalho, Edgar Marcelino de Carvalho, David M. Mosser, Aloisio Falqueto, Arne N. Akbar, Daniel Claudio Oliveira Gomes
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2024-10-01
Serie:Frontiers in Immunology
Soggetti:
CD4-CTL
cutaneous leishmaniasis
Leishmania braziliensis
senescent cells
bystander cytotoxicity
Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1475146/full
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