Design of New α-Conotoxins: From Computer Modeling to Synthesis of Potent Cholinergic Compounds
A series of 14 new analogs of α-conotoxin PnIA Conus pennaceus was synthesized and tested for binding to the human α7 nicotinic acetylcholine receptor (nAChR) and acetylcholine-binding proteins (AChBP) Lymnaea stagnalis and Aplysia californica. Based on computer modeling and the X-ray structure of t...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
MDPI AG
2011-09-01
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| coleção: | Marine Drugs |
| Assuntos: | |
| Acesso em linha: | http://www.mdpi.com/1660-3397/9/10/1698/ |
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