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Tertiary lymphoid structures: exploring opportunities to improve immunotherapy in ovarian cancer

Tertiary lymphoid structures (TLS) are organized ectopic lymphoid clusters of immune cells that develop in non-lymphoid tissue to promote antigen presentation, drive cytotoxic immune responses, and enhance humoral immunity via B cell clonal expansion. Their presence within the tumor microenvironment...

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Principais autores: Aaron Varghese, Suzanne M. Hess, Shanmuga Chilakapati, Jose R. Conejo-Garcia, A.J. Robert McGray, Emese Zsiros
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-05-01
Serier:Frontiers in Immunology
Fag:
tertiary lymphoid structures
ovarian cancer
immunotherapy
tumor microenvironment
gut microbiome
biomarkers
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1473969/full
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