Nano-Zirconium Dioxide Catalyzed Multicomponent Synthesis of Bioactive Pyranopyrazoles That Target Cyclin Dependent Kinase 1 in Human Breast Cancer Cells

Small molecules are being used to inhibit cyclin dependent kinase (CDK) enzymes in cancer treatment. There is evidence that CDK is a drug-target for cancer therapy across many tumor types because it catalyzes the transfer of the terminal phosphate of ATP to a protein that acts as a substrate. Herein...

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Váldodahkkit:	Basappa Basappa, Lisha K. Poonacha, Zhang Xi, Divakar Vishwanath, Ji-Rui Yang, Omantheswara Nagaraja, Ananda Swamynayaka, Mahendra Madegowda, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Doddahosuru Mahadevappa Gurudatt, Vijay Pandey, Nanjundaswamy Shivananju, Kwang Seok Ahn, Gautam Sethi, Peter E. Lobie, Priya Babu Shubha
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	MDPI AG 2023-01-01
Ráidu:	Biomedicines
Fáttát:	pyranopyrazoles CDK1 Gibbs free energy CHEMBL nano-zirconium dioxide
Liŋkkat:	https://www.mdpi.com/2227-9059/11/1/172
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