Development of Piperazine- and Oxazine-Linked Pyrimidines as p65 Subunit Binders of NF–κB in Human Breast Cancer Cells

Nuclear factor kappa B (NF–κB) is a potential therapeutic target in breast cancer. In the current study, a new class of oxazine– and piperazine–linked pyrimidines was developed as inhibitors of NF–κB, overcoming the complexity of the oxazine structure found in nature and enabling synthesis under lab...

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Autors principals:	Akshay Ravish, Bhanuprakash C. Narasimhachar, Zhang Xi, Divakar Vishwanath, Arunkumar Mohan, Santosh L. Gaonkar, Paduvalahippe Gowdegowda Chandrashekara, Kwang Seok Ahn, Vijay Pandey, Peter E. Lobie, Basappa Basappa
Format:	Artigo
Idioma:	Inglês
Publicat:	MDPI AG 2023-10-01
Col·lecció:	Biomedicines
Matèries:	oxazines piperazines pyrimidines NF–κB Alamar Blue assay molecular docking
Accés en línia:	https://www.mdpi.com/2227-9059/11/10/2716
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