Adipocyte FMO3-derived TMAO induces WAT dysfunction and metabolic disorders by promoting inflammasome activation in ageing

Abstract Trimethylamine N-oxide (TMAO) contributes to cardio-metabolic diseases, with hepatic flavin-containing monooxygenase 3 (FMO3) recognized as its primary source. Here we demonstrate that elevated adipocyte FMO3 and its derived TMAO trigger white adipose tissue (WAT) dysfunction and its relate...

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Autori principali: Thashma Ganapathy, Juntao Yuan, Melody Yuen-man Ho, Kelvin Ka-lok Wu, Md Moinul Hoque, Baomin Wang, Xiaomu Li, Kai Wang, Martin Wabitsch, Xuejia Feng, Yongxia Niu, Kekao Long, Qizhou Lian, Yuyan Zhu, Kenneth King-yip Cheng
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Portfolio 2025-10-01
Serie:Nature Communications
Accesso online:https://doi.org/10.1038/s41467-025-63905-1
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