Heterozygous GBA D409V and ATP13a2 mutations do not exacerbate pathological α-synuclein spread in the prodromal preformed fibrils model in young mice

Autophagic dysregulation and lysosomal impairment have been implicated in the pathogenesis of Parkinson's disease, partly due to the identification of mutations in multiple genes involved in these pathways such as GBA, SNCA, ATP13a2 (also known as PARK9), TMEM175 and LRRK2. Mutations resulting in ly...

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Hlavní autoři:	Michaela E. Johnson, Liza Bergkvist, Lucas Stetzik, Jennifer A. Steiner, Lindsay Meyerdirk, Emily Schulz, Emily Wolfrum, Kelvin C. Luk, Daniel W. Wesson, Dimitri Krainc, Patrik Brundin
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2021-11-01
Edice:	Neurobiology of Disease
Témata:	Parkinson's disease GBA ATP13a2 α-Synuclein preformed fibrils Olfactory bulb
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S096999612100262X
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