Can the SARS-CoV-2 Spike Protein Bind Integrins Independent of the RGD Sequence?

The RGD motif in the Severe Acute Syndrome Coronavirus 2 (SARS-CoV-2) spike protein has been predicted to bind RGD-recognizing integrins. Recent studies have shown that the spike protein does, indeed, interact with αVβ3 and α5β1 integrins, both of which bind to RGD-containing ligands. However, compu...

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Principais autores:	Christopher A. Beaudoin, Samir W. Hamaia, Christopher L.-H. Huang, Tom L. Blundell, Antony P. Jackson
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2021-11-01
סדרה:	Frontiers in Cellular and Infection Microbiology
נושאים:	SARS-CoV-2 SARS-CoV-2 spike protein integrin integrin-binding motif RGD bioinformatics
גישה מקוונת:	https://www.frontiersin.org/articles/10.3389/fcimb.2021.765300/full
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