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BAM15‐mediated mitochondrial uncoupling protects against obesity and improves glycemic control

Abstract Obesity is a leading cause of preventable death worldwide. Despite this, current strategies for the treatment of obesity remain ineffective at achieving long‐term weight control. This is due, in part, to difficulties in identifying tolerable and efficacious small molecules or biologics capa...

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Principais autores: Christopher L Axelrod, William T King, Gangarao Davuluri, Robert C Noland, Jacob Hall, Michaela Hull, Wagner S Dantas, Elizabeth RM Zunica, Stephanie J Alexopoulos, Kyle L Hoehn, Ingeborg Langohr, Krisztian Stadler, Haylee Doyle, Eva Schmidt, Stephan Nieuwoudt, Kelly Fitzgerald, Kathryn Pergola, Hisashi Fujioka, Jacob T Mey, Ciaran Fealy, Anny Mulya, Robbie Beyl, Charles L Hoppel, John P Kirwan
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Nature 2020-06-01
coleção:EMBO Molecular Medicine
Assuntos:
AMPK
BAM15
mitochondria
obesity
type 2 diabetes
Acesso em linha:https://doi.org/10.15252/emmm.202012088
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